Underneath the Lost Kilos: Imaging insights for body composition, muscle changes and other downstream effects in GLP-1 RA trials

  • Clarifying what weight loss is made of: Imaging distinguishes changes in fat, lean tissue and muscle composition, giving a clearer view of treatment effects than body weight alone.
  • Understanding muscle preservation and performance: Muscle preservation, composition and functional capacity are important to evaluate in clinical trials, and imaging helps characterise these changes in a consistent and reliable way.
  • Revealing wider biological effects: Weight loss influences multiple organs and metabolic pathways. Imaging makes these downstream changes visible, helping determine whether a therapy delivers meaningful and durable health benefits